Studies on the bioactive constituents of the Formosan soft coral Cespitularia hypotentaculata
Eight new metabolites (1-5 and 7-9) and one known compound were isolated from the acetone/methylene chloride (1:1)extracts of the Formosan soft coral Cespitularia hypotenta-culata. These compounds can be divided into five groups: cespitularin I (1), having the verticillane skeleton, cespitularin J (...
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NSYSU
18.02.2005
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| Abstract | Eight new metabolites (1-5 and 7-9) and one known compound were isolated from the acetone/methylene chloride (1:1)extracts of the Formosan soft coral Cespitularia hypotenta-culata. These compounds can be divided into five groups: cespitularin I (1), having the verticillane skeleton, cespitularin J (2), that possesses the norverticillane skeleton, cespitularin K (3)¡B6-acetoxycespitularin F (4) and cespitularin L (5), possessing the cespitularane skeleton, (24S)-3£],11-dihydroxy-5£],6£]-epoxy-24-methyl-9,11-secocholestan-9-one (6), 3£],11-dihydroxy-5£],6£]-epoxy-9,11-secocholestan-9-one (7), and 3£]-hydroxy-5£],6£]-epoxy-9-oxo-9,11-secogorgo-stan-11-ol (8) are secosterols, and xenia diterpene, cespolide A (9). All of these structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro. |
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| AbstractList | Eight new metabolites (1-5 and 7-9) and one known compound were isolated from the acetone/methylene chloride (1:1)extracts of the Formosan soft coral Cespitularia hypotenta-culata. These compounds can be divided into five groups: cespitularin I (1), having the verticillane skeleton, cespitularin J (2), that possesses the norverticillane skeleton, cespitularin K (3)¡B6-acetoxycespitularin F (4) and cespitularin L (5), possessing the cespitularane skeleton, (24S)-3£],11-dihydroxy-5£],6£]-epoxy-24-methyl-9,11-secocholestan-9-one (6), 3£],11-dihydroxy-5£],6£]-epoxy-9,11-secocholestan-9-one (7), and 3£]-hydroxy-5£],6£]-epoxy-9-oxo-9,11-secogorgo-stan-11-ol (8) are secosterols, and xenia diterpene, cespolide A (9). All of these structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro. |
| Author | Li, Chia-hua |
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| CorporateAuthor | Jyh-Horng Sheu Ya-Ching Shen Chang-Yih Duh |
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| Title | Studies on the bioactive constituents of the Formosan soft coral Cespitularia hypotentaculata |
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