Dipeptide nitriles

• Main Authors: KEIGO GOHDA, MARTIN MISSBACH, MIYUKI HORIUCHI, RENE LATTMANN, RUBEN ALBERTO TOMMASI, JUNICHI SASAKI, PAUL DAVID GREENSPAN, JOHN HENRY VAN DUZER, MICHIHIRO TAKAI, CLAUDIA BETSCHART, SCOTT DOUGLAS COWEN, EVA ALTMANN, NAOKI TENO, LESLIE WIGHTON MCQUIRE
• Format: Patent
• Language: English
• Published: 05.05.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

N-terminal substituted dipeptide nitriles as defined are useful as inhibitors of cysteine cathepsins, e.g. cathepsins B, K, L and S, and can be used for the treatment of cysteine cathepsin dependent diseases and conditions, including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis,...