Novel steroids with pregnane skeleton, pharmaceutical compositions containing them and process for preparing same

• Main Authors: ERZSEBET FRANCSICS NEE CZINEGE, SANSOE GOEROEG, LASZLO SZPORNY, ANNA BOOR NEE MEZEL, SANDOR MAHO, ANIKO GERE, PAL VITTAY, EVA PALOSI, BELA KISS, GABOR BALOGH, ZOLTAN TUBA
• Format: Patent
• Language: English
• Published: 06.01.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

PCT No. PCT/HU93/00035 Sec. 371 Date Dec. 8, 1994 Sec. 102(e) Date Dec. 8, 1994 PCT Filed Jun. 8, 1993 PCT Pub. No. WO93/25570 PCT Pub. Date Dec. 23, 1993Novel, therapeutically active 21-aminosteroids of formula (I) (I) with pregnane skeleton, are disclosed wherein two of X, Y and Z are a nitrogen atom each and the third one is a methine group; R1 and R2 are independently from each other, a primary amino group bearing as substituent a branched-chain C4-8alkyl -alkenyl or -alkynyl group, or a C4-10cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by at least one C1-3alkyl group; or R1 and R2 are each a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R1 and R2 is an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by at least one C1-4alkyl group; and n is 1 or 2, as well as their acid addition salts and pharmaceutical compositions containing these compounds.