DETECTION AND ISOLATION OF DESCRETE,TRANSMISSIBLE,MAMMALIAN GENES ASSOCIATED WITH TUMOR METASTASIS

• Main Authors: ROBERT A. WEINBERG, SHELLY C. BERNSTEIN
• Format: Patent
• Language: English
• Published: 30.07.1986
• Edition: 4
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; TESTING; VINEGAR; WINE

A method for detecting a discrete, transmissible, mammalian gene associated with tumor metastasis. Using the method, a gene associated with metastasis and originating in the human cervical carcinoma line ME-180, metastatic to omentum, and a gene associated with metastasis and originating in the human neuroblastoma cell line SK-N-MC, metastatic to the supraorbital area, have been detected and identified.