NANO-PARTICLES THAT CONTAIN SYNTHETIC VARIANTS OF GM3 GANGLIOSIDE AS ADJUVANTS IN VACCINES

This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the hum...

Full description

Saved in:
Bibliographic Details
Main Authors MESA PARDILLO, Circe, LÓPEZ LÓPEZ, Miguel Antonio, SÁNCHEZ RAMÍREZ, Belinda, TOLÓN MURGUÍA, Blanca Idelmis, JUNCO BARRANCO, Jesús Arturo, VEREZ BENCOMO, Vicente Guillermo, CRUZ RODRÍGUEZ, Mabel, FERNÁNDEZ MOLINA, Luis Enrique, PÉREZ MARTÍNEZ, Dayana, HERNÁNDEZ FERNÁNDEZ, Diana Rosa, FERNÁNDEZ GÓMEZ, Audry, BERGADO BÁEZ, Gretchen, MANSO VARGAS, Ángel Alexis, CHAO GARCÍA, Lisset, GONZÁLEZ SUÁREZ, Narjara
Format Patent
LanguageEnglish
Published 25.05.2022
Online AccessGet full text

Cover

Abstract This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) ofNeisseria meningitidisin solutions containing fully synthetic variants of the GM3 ganglioside.
AbstractList This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) ofNeisseria meningitidisin solutions containing fully synthetic variants of the GM3 ganglioside.
Author FERNÁNDEZ MOLINA, Luis Enrique
PÉREZ MARTÍNEZ, Dayana
CRUZ RODRÍGUEZ, Mabel
GONZÁLEZ SUÁREZ, Narjara
BERGADO BÁEZ, Gretchen
LÓPEZ LÓPEZ, Miguel Antonio
TOLÓN MURGUÍA, Blanca Idelmis
FERNÁNDEZ GÓMEZ, Audry
SÁNCHEZ RAMÍREZ, Belinda
HERNÁNDEZ FERNÁNDEZ, Diana Rosa
VEREZ BENCOMO, Vicente Guillermo
MESA PARDILLO, Circe
JUNCO BARRANCO, Jesús Arturo
CHAO GARCÍA, Lisset
MANSO VARGAS, Ángel Alexis
Author_xml – fullname: MESA PARDILLO, Circe
– fullname: LÓPEZ LÓPEZ, Miguel Antonio
– fullname: SÁNCHEZ RAMÍREZ, Belinda
– fullname: TOLÓN MURGUÍA, Blanca Idelmis
– fullname: JUNCO BARRANCO, Jesús Arturo
– fullname: VEREZ BENCOMO, Vicente Guillermo
– fullname: CRUZ RODRÍGUEZ, Mabel
– fullname: FERNÁNDEZ MOLINA, Luis Enrique
– fullname: PÉREZ MARTÍNEZ, Dayana
– fullname: HERNÁNDEZ FERNÁNDEZ, Diana Rosa
– fullname: FERNÁNDEZ GÓMEZ, Audry
– fullname: BERGADO BÁEZ, Gretchen
– fullname: MANSO VARGAS, Ángel Alexis
– fullname: CHAO GARCÍA, Lisset
– fullname: GONZÁLEZ SUÁREZ, Narjara
BookMark eNqNi0sOgjAUALvQhb87PA9AgnTj9lkKrcFXQ58ksiHE1JUpJHj_SIwHcDWLmVmLRRxiWImWkFxyxZqtqrQHNsigHDFaAn8nNno20GBtkdiDK6C8SCiRyso6b3MN6AHz8635-vlqUClL2m_F8tm_prD7cSP2hWZlkjAOXZjG_hFieHctZmmWpjI7HE_yn-YDjCczYg
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID ZA202003218B
GroupedDBID EVB
ID FETCH-epo_espacenet_ZA202003218B3
IEDL.DBID EVB
IngestDate Fri Aug 30 05:42:24 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_ZA202003218B3
Notes Application Number: ZA20200003218
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220525&DB=EPODOC&CC=ZA&NR=202003218B
ParticipantIDs epo_espacenet_ZA202003218B
PublicationCentury 2000
PublicationDate 20220525
PublicationDateYYYYMMDD 2022-05-25
PublicationDate_xml – month: 05
  year: 2022
  text: 20220525
  day: 25
PublicationDecade 2020
PublicationYear 2022
RelatedCompanies CENTRO DE INMUNOLOGÍA MOLECULAR
RelatedCompanies_xml – name: CENTRO DE INMUNOLOGÍA MOLECULAR
Score 3.3988051
Snippet This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine...
SourceID epo
SourceType Open Access Repository
Title NANO-PARTICLES THAT CONTAIN SYNTHETIC VARIANTS OF GM3 GANGLIOSIDE AS ADJUVANTS IN VACCINES
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220525&DB=EPODOC&locale=&CC=ZA&NR=202003218B
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fT8IwEL4gGvVNUYP4IzUxe1ucwGB7IKZ0GxuBjrCxIC-ENSXRh0Fkxn_f6wLii741_dKmvfT6tb3eHcCjIdupLRqGbgn1dGOJpW5braWOqpQukFBM41k5OA95y580-1NzWoL3nS9MESf0qwiOiBolUN_zYr9e7x-xnOJv5eYpfcOq1YsXdxxteztWXqN1U3O6HXcUOiHTGOvMqMbHCsP1i3zWPYBDdYxWcfbdpKu8Uta_KcU7g6MR9pbl51CSWQVO2C7zWgWOh1uDNxa3ure5gBmnPNRHeAAN2MCNSOzTmLCQxzTgJHrlse8iQhI6DiiPIxJ6pDdskB7lvUEQRoHjEhoR6vQnSYFjq4QyprJuXMKD58bM13GQ8x-JzGd0P5_GFZSzVSarQBbSkBbupO2milQmbNuUpiFFKhbNFHmodQ21v_up_QfewKmSrjKb181bKOcfn_IO2ThP7wsxfgOMkYbt
link.rule.ids 230,309,786,891,25594,76906
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fT8IwEL4gGvFNUaP4qyZmb4sTGGwPxJRuY8OtI6wQ5IWwZST6MIjM-O97XUB80bemX9q0l16_tte7A3jQ0nZsJg1NNRL5dGMkC9U0WgsVVSmeI6Ho2pN0cA54yx01-xN9UoL3rS9MESf0qwiOiBqVoL7nxX692j1iWcXfyvVj_IZVy2dHdCxlczuWXqN1XbG6HXsQWiFTGOtMqcKHEsP1i3zW3YP9tozOK49O4670Sln9phTnGA4G2FuWn0ApzapQYdvMa1U4DDYGbyxudG99ClNOeagO8ADqMd-OiHCpICzkgnqcRK9cuDYiZEyHHuUiIqFDekGD9Cjv-V4YeZZNaESo1R-NCxxbjSljMuvGGdw7tmCuioOc_UhkNqW7-TTOoZwts_QCyDzVUgN30nZTRipLTFNPdS1N4mTejJGHWpdQ-7uf2n_gHVRcEfgz3-MvV3AkJS1N6HX9Gsr5x2d6g8ycx7eFSL8BBOiJ2g
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=NANO-PARTICLES+THAT+CONTAIN+SYNTHETIC+VARIANTS+OF+GM3+GANGLIOSIDE+AS+ADJUVANTS+IN+VACCINES&rft.inventor=MESA+PARDILLO%2C+Circe&rft.inventor=L%C3%93PEZ+L%C3%93PEZ%2C+Miguel+Antonio&rft.inventor=S%C3%81NCHEZ+RAM%C3%8DREZ%2C+Belinda&rft.inventor=TOL%C3%93N+MURGU%C3%8DA%2C+Blanca+Idelmis&rft.inventor=JUNCO+BARRANCO%2C+Jes%C3%BAs+Arturo&rft.inventor=VEREZ+BENCOMO%2C+Vicente+Guillermo&rft.inventor=CRUZ+RODR%C3%8DGUEZ%2C+Mabel&rft.inventor=FERN%C3%81NDEZ+MOLINA%2C+Luis+Enrique&rft.inventor=P%C3%89REZ+MART%C3%8DNEZ%2C+Dayana&rft.inventor=HERN%C3%81NDEZ+FERN%C3%81NDEZ%2C+Diana+Rosa&rft.inventor=FERN%C3%81NDEZ+G%C3%93MEZ%2C+Audry&rft.inventor=BERGADO+B%C3%81EZ%2C+Gretchen&rft.inventor=MANSO+VARGAS%2C+%C3%81ngel+Alexis&rft.inventor=CHAO+GARC%C3%8DA%2C+Lisset&rft.inventor=GONZ%C3%81LEZ+SU%C3%81REZ%2C+Narjara&rft.date=2022-05-25&rft.externalDBID=B&rft.externalDocID=ZA202003218B