TETRAHYDROOXEPINOPYRIDINE COMPOUND

[Problem] To provide a compound which has a positive allosteric modulating effect (PAM effect) for an ±7 nicotinic acetylcholine receptor (±7 nACh receptor). [Solution] The inventors have achieved the present invention by making studies on PAM effects for an ±7 nACh receptor and confirming that a te...

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Main Authors SHUICHIROU KAKIMOTO, SATOSHI MIYAMOTO, YUKA KOIZUMI, SATOSHI AOKI, SHINYA NAGASHIMA, SHIMPEI KAWAKAMI, SHIGEKI KUNIKAWA, KOICHI YONEZAWA, HIROSHI YAMADA, KEISUKE TAMAKI, TAKASHI OGIYAMA, JUNICHI SHISHIKURA, YOHEI KOGANEMARU, AKIO KAMIKAWA, RYO SATO
Format Patent
LanguageEnglish
Published 24.04.2019
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Summary:[Problem] To provide a compound which has a positive allosteric modulating effect (PAM effect) for an ±7 nicotinic acetylcholine receptor (±7 nACh receptor). [Solution] The inventors have achieved the present invention by making studies on PAM effects for an ±7 nACh receptor and confirming that a tetrahydrooxepinopyridine compound has a PAM effect for an ±7 nACh receptor. A tetrahydrooxepinopyridine compound according to the present invention has a PAM effect for an ±7 nACh receptor, and is promising as a prophylactic or therapeutic agent for dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases or pain.
Bibliography:Application Number: ZA20180001098