HOST CELLS AND METHODS FOR PRODUCTION OF ISOBUTANOL

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activ...

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Main Authors HUANG LISA L, MCELVAIN JESSICA, GIBSON KATHARINE J, HE HONGXIAN, PATNAIK RANJAN, LI YOUGEN, O'KEEFE DANIEL P, NELSON MARK J, ROTHMAN STEVEN CARY, ANTHONY LARRY CAMERON, MAGGIO-HALL LORI ANN, KRUCKEBERG ARTHUR LEO
Format Patent
LanguageEnglish
Published 28.01.2015
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
Bibliography:Application Number: ZA20130006708