PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE

The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of...

Full description

Saved in:
Bibliographic Details
Main Authors DURRANT STEVEN, MORTIMORE MICHAEL, O'DONNELL MICHAEL, KAY DAVID, CHARRIER JEAN-DAMIEN, YOUNG STEPHEN, REAPER PHILIP MICHAEL, PINDER JOANNE, KNEGTEL RONALD, RUTHERFORD ALISTAIR, VIRANI ANISA NIZARALI, MACCORMICK SOMHAIRLE
Format Patent
LanguageEnglish
Published 31.10.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I):wherein the variables are as defined herein.
Bibliography:Application Number: ZA20110004498