Gene disruptions, compositions and methods relating thereto

• Main Authors: SPARKS, MARY JEAN, SEVAUX, TRACY ELLEN WILLIS, PEALE JR., FRANKLIN, FAN, LIANGFEN, MCLAIN TOM DINA REBECCA, WANG, CHING-YUN, CULBERTSON, LING LING, ROHRER, MICHELLE, SHI, ZHENG-ZHENG, MONTGOMERY, CHARLES A, VOGEL, PETER, COMBS, KATHERIN E, STALA, JOY ANNE, PHILLIPS, HEIDI, HORNER, ALLISON ANNE BYERS, GREEN, LESLIE JANE, PAYNE, BOBBY JOE, XIONG, WEN, DE SAUVAGE, FREDERIC J, DELMAS-MATA, JUAN, MASSEY, ERIN MARIE, FRANTZ, GRETCHEN, TANG, TRACY TZU-LING
• Format: Patent
• Language: English
• Published: 28.10.2009
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO112 PRO1134 PRO115 PRO1281 PRO1343 PRO1379 PRO1380 PRO1387 PRO1419 PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196 PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.