Process for the synthesis of chirally pure beta-amino-alcohols

• Main Authors: LYNN RESNICK, KUBRAK DENNIS MARTIN, MADELENE MIYOKO ANTANE, JOSEPH RAYMOND STOCK, ANTHONY FRANK KREFT, ZHENG WANG, DEREK CECIL COLE
• Format: Patent
• Language: English
• Published: 10.10.2005
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A process is provided for preparing chirally pure S-enantiomers of alpha-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R)2CH(CH2)nCH2X; b) adding the organometallic reagent to carbon dioxide to afford a carboxylic acid; c) activating...