Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems

• Main Authors: TIMOTHY NORRIS, MEGAN ELIZABETH HNATOW, JOHN FRANCIS LAMBERT
• Format: Patent
• Language: English
• Published: 28.02.2002
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A novel process intermediate, tetrahydro-4- 3-(4-fluorophenyl)thio­phenyl-2H-pyran-4-carboxamide, of the formula: is described, as well as its use in a process of preparing 5-lipoxygenase inhibitors of the formula: which comprises establishing a reaction mixture consisting of: - and - an electron de...