PROCESS FOR OBTAINING TRANS-4-PHENYL-1,2,3,4-TETRAHYDRO-1-NAPHTHALENE AMINE
Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The p...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
30.09.1983
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Edition | 3 |
Subjects | |
Online Access | Get full text |
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Abstract | Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphth alenamine and its pharmaceutically acceptable acid addition salts. |
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AbstractList | Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphth alenamine and its pharmaceutically acceptable acid addition salts. |
Author | HERBERT C.A KRASKA A.R MCKOWAN WELCH W KOE B.K |
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Snippet | Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the... |
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Title | PROCESS FOR OBTAINING TRANS-4-PHENYL-1,2,3,4-TETRAHYDRO-1-NAPHTHALENE AMINE |
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