PROCESS FOR OBTAINING TRANS-4-PHENYL-1,2,3,4-TETRAHYDRO-1-NAPHTHALENE AMINE

Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The p...

Full description

Saved in:
Bibliographic Details
Main Authors KOE B.K, HERBERT C.A, KRASKA A.R, MCKOWAN WELCH W
Format Patent
LanguageEnglish
Published 30.09.1983
Edition3
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

Abstract Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphth alenamine and its pharmaceutically acceptable acid addition salts.
AbstractList Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphth alenamine and its pharmaceutically acceptable acid addition salts.
Author HERBERT C.A
KRASKA A.R
MCKOWAN WELCH W
KOE B.K
Author_xml – fullname: KOE B.K
– fullname: HERBERT C.A
– fullname: KRASKA A.R
– fullname: MCKOWAN WELCH W
BookMark eNrjYmDJy89L5WTwDgjyd3YNDlZw8w9S8HcKcfT08_RzVwgJcvQL1jXRDfBw9Yv00TXUMdIx1jHRDXEFSnhEugT56xrq-jkGeIR4OPq4-rkqOPp6-rnyMLCmJeYUp_JCaW4GOTfXEGcP3dSC_PjU4oLE5NS81JL4yFAjc3MTCwNHY4IKAGENLc4
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
Edition 3
ExternalDocumentID YU277480A
GroupedDBID EVB
ID FETCH-epo_espacenet_YU277480A3
IEDL.DBID EVB
IngestDate Fri Jul 19 13:00:00 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_YU277480A3
Notes Application Number: YU19800002774
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830930&DB=EPODOC&CC=YU&NR=277480A
ParticipantIDs epo_espacenet_YU277480A
PublicationCentury 1900
PublicationDate 19830930
PublicationDateYYYYMMDD 1983-09-30
PublicationDate_xml – month: 09
  year: 1983
  text: 19830930
  day: 30
PublicationDecade 1980
PublicationYear 1983
RelatedCompanies PFIZER INC
RelatedCompanies_xml – name: PFIZER INC
Score 2.366058
Snippet Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the...
SourceID epo
SourceType Open Access Repository
SubjectTerms ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PROCESS FOR OBTAINING TRANS-4-PHENYL-1,2,3,4-TETRAHYDRO-1-NAPHTHALENE AMINE
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830930&DB=EPODOC&locale=&CC=YU&NR=277480A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3dT4MwEL_oNOqbzu-PhQfD0xo3KAweiGHQyXQrBJkZTwsFanxhi8P471vYpr7srWmTy_XS69317ncFuOe6OBaKwhBL0irNyDlivKejJM94qnCu8aRCI4-p7k3w81Sb7sD7BgtT9wn9rpsjCo1Khb6X9X29-HvEcuvayuUD-xBT88dBZLlytoKLGVVeryO7fYsEvus7suNY8USmoaUIN8fo2LuwV_nQVZN98tavICmL__ZkcAz7gSBVlCewkxdNOHQ236414WC8znaL4VrxlqfwEoS-I2QliaBN8vuRPaRD-iRFoU1fEUaBR2g8Qt220lbbGEVELHixG_oidKN24EWePSKUSPZ4SMkZtAYkcjwkuJr97n8WT9bcq-fQKOZFfgmSauaZlhpYTdUEd3jXMHWOMy1hPZabZoqv4GILkeutKzdwVIlwVQ1xC43y8yu_Eya3ZK1aXD-9NYGI
link.rule.ids 230,309,786,891,25594,76903
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1LT4NAEJ7Uaqw3re9H5WA4dWPLq3AghgIVLCwEqSknwmuNF9pYjH_fhbbqpbfNTjKZnezs7LfzWIAHItFtwXEpSpOsDjMSglIyklBS5CTjCBFJUlcju1iyZsLLXJy34H1bC9P0Cf1umiNSi8qovVfNeb38e8QymtzK1WP6QacWT5NQNdh8XS4m13G9AWuMVdP3DE9ndV2NZiwOVI5ec-SBtgf7I4oHG5z0Nq5LUpb__cnkGA58yqqsTqBVlF3o6Ntv17pw6G6i3XS4MbzVKUz9wNOprhgK2hhvHGo2tvEzEwYafkUC8i0TRw4a9rk-3xdQaFKCFRmBR6Eb1nwrtDTHxCajuTY2z6A3MUPdQlSq-Hf9cTTbSM-fQ7tclMUlMLxS5GImC3zGJ8KADGVFIkIuJukoLRQlE67gYgeT652Ue-hYoevEjo2nN3BUq3OdGXEL7erzq7ij7rdKe43qfgDv_4Ry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=PROCESS+FOR+OBTAINING+TRANS-4-PHENYL-1%2C2%2C3%2C4-TETRAHYDRO-1-NAPHTHALENE+AMINE&rft.inventor=KOE+B.K&rft.inventor=HERBERT+C.A&rft.inventor=KRASKA+A.R&rft.inventor=MCKOWAN+WELCH+W&rft.date=1983-09-30&rft.externalDBID=A&rft.externalDocID=YU277480A