IMPROVED PROCESS FOR PRODUCING 4-HYDROXY-2-PYRROLIDONE

An improved process for producing 4-hydroxy-2-pyrrolidone represented by formula (1), which is useful as an intermediate for synthesizing medicines, agricultural chemicals and so forth, by synthesizing a 4-azido-3-hydroxybutanoic ester by the reaction of a 4-halogeno-3-hydroxybutanoic ester with an...

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Bibliographic Details
Main Authors FURUKAWA, YOSHIRO, SHIOMI, YUTAKA, NAGAO, KENICHI
Format Patent
LanguageEnglish
French
Japanese
Published 21.11.1996
Edition6
Subjects
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:An improved process for producing 4-hydroxy-2-pyrrolidone represented by formula (1), which is useful as an intermediate for synthesizing medicines, agricultural chemicals and so forth, by synthesizing a 4-azido-3-hydroxybutanoic ester by the reaction of a 4-halogeno-3-hydroxybutanoic ester with an alkali metal or alkaline earth metal azide followed by the catalytic reduction of the azido group of the ester and cyclization. L'invention concerne un procédé amélioré pour préparer la 4-hydroxy-2-pyrrolidone représentée par la formule (1), qui est utile comme intermédiaire pour synthétiser des médicaments, des composés utiles en agriculture, etc. Ce procédé consiste à synthétiser un ester de l'acide 4-azido-3-hydroxybutyrique par la réaction d'un ester d'un acide 4-halogéno-3-hydroxybutyrique avec un azoture de métal alcalin ou alcalino-terreux, suivie par la réduction catalytique du groupe azido de l'ester et cyclisation pour obtenir le composé (1).
Bibliography:Application Number: WO1996JP01259