3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal t...

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Main Authors NUTT, RUTH, F, LIM-WILBY, MARGUERITA, S., L, ROWLEY, DAVID, C, BRUNCK, TERRENCE, K, RIPKA, WILLIAM, CHARLES, SEMPLE, JOSEPH, EDWARD, ARDECKY, ROBERT, J
Format Patent
LanguageEnglish
French
Published 28.12.1995
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis. La présente invention concerne des aldéhydes de peptides qui sont des inhibiteurs puissants et spécifiques de la thrombine, leurs sels pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables de ces derniers. L'invention a également pour objet des procédés pour les utiliser comme agents thérapeutiques pour soigner des maladies chez le mammifère, caractérisées par une thrombose anormale.
Bibliography:Application Number: WO1995US07661