SECRETED MAC-2-BINDING GLYCOPROTEIN

• Main Authors: HALENBECK, ROBERT, WANG, ALICE, M, KOTHS, KIRSTON, E, TAYLOR, ERIC, W, CASIPIT, CLAYTON, L
• Format: Patent
• Language: English
• Published: 29.04.1993
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

A purified glycoprotein complex of over 1200 kD apparent native molecular weight having a sedimentation value of approximately 25S and having the ability to selectively bind human Mac-2 or interfere with PHA activation of lymphocytes, DNA sequences that encode the protein, and expression systems for expressing it, thus providing for medicaments that are useful for treating or diagnosing diseases, including cancer, infectious disease, and diseases of the immune system. Complexe glycoprotéique purifié à poids moléculaire natif apparent supérieur à 1200 kD et à valeur de sédimentation d'environ 25S, pouvant se lier de manière sélective au Mac-2 humain, ou perturber l'activation de phytohémagglutinine par les lymphocytes; séquences d'ADN codant ladite protéine; et systèmes d'expression l'exprimant. On obtient ainsi des médicaments utilisés dans le traitement et le diagnostic de maladies, notamment du cancer, des maladies infectieuses et des maladies du système immunitaire.