SINGLE DOMAIN VHH ANTIBODIES AGAINST HANTAVIRUS
The present invention provides alpaca derived VHHs, therapeutic agents, compositions and methods for the prevention, amelioration and treatment of Hantavirus infections. The inventors obtained two neutralizing single domain VHH antibodies, VHH1 and VHH2 that specifically recognize hantavirus glycopr...
Saved in:
| Main Authors | , , , , |
|---|---|
| Format | Patent |
| Language | English French |
| Published |
10.10.2024
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present invention provides alpaca derived VHHs, therapeutic agents, compositions and methods for the prevention, amelioration and treatment of Hantavirus infections. The inventors obtained two neutralizing single domain VHH antibodies, VHH1 and VHH2 that specifically recognize hantavirus glycoproteins Gn/Gc presented on Viral-like Particles (VLPs). The invention also provides a method for the detection of Hantavirus in a sample and a method for the neutralization of Hantavirus, with VHH1 and VHH2 where the in vivo neutralization of the virus allows to control the disease in an individual.
La présente invention concerne des VHH dérivés d'alpaca, des agents thérapeutiques, des compositions et des procédés pour la prévention, le soulagement et le traitement d'infections par hantavirus. Les inventeurs ont obtenu deux anticorps VHH à domaine unique de neutralisation, VHH1 et VHH2 qui reconnaissent de manière spécifique des glycoprotéines de hantavirus Gn/Gc présentées sur des particules de type viral (VLP). L'invention concerne également un procédé de détection de hantavirus dans un échantillon et un procédé de neutralisation de hantavirus, avec VHH1 et VHH2 où la neutralisation in vivo du virus permet de lutter contre la maladie chez un individu. |
|---|---|
| AbstractList | The present invention provides alpaca derived VHHs, therapeutic agents, compositions and methods for the prevention, amelioration and treatment of Hantavirus infections. The inventors obtained two neutralizing single domain VHH antibodies, VHH1 and VHH2 that specifically recognize hantavirus glycoproteins Gn/Gc presented on Viral-like Particles (VLPs). The invention also provides a method for the detection of Hantavirus in a sample and a method for the neutralization of Hantavirus, with VHH1 and VHH2 where the in vivo neutralization of the virus allows to control the disease in an individual.
La présente invention concerne des VHH dérivés d'alpaca, des agents thérapeutiques, des compositions et des procédés pour la prévention, le soulagement et le traitement d'infections par hantavirus. Les inventeurs ont obtenu deux anticorps VHH à domaine unique de neutralisation, VHH1 et VHH2 qui reconnaissent de manière spécifique des glycoprotéines de hantavirus Gn/Gc présentées sur des particules de type viral (VLP). L'invention concerne également un procédé de détection de hantavirus dans un échantillon et un procédé de neutralisation de hantavirus, avec VHH1 et VHH2 où la neutralisation in vivo du virus permet de lutter contre la maladie chez un individu. |
| Author | TISCHLER, Nicole ROJAS-FERNÁNDEZ, Alejandro JARA, Ronald MUENA CASTILLO, Nicolás Alvaro VALENZUELA-NIETO, Guillermo |
| Author_xml | – fullname: TISCHLER, Nicole – fullname: VALENZUELA-NIETO, Guillermo – fullname: JARA, Ronald – fullname: MUENA CASTILLO, Nicolás Alvaro – fullname: ROJAS-FERNÁNDEZ, Alejandro |
| BookMark | eNrjYmDJy89L5WTQD_b0c_dxVXDx93X09FMI8_BQcPQL8XTyd_F0DVZwdAcKBocoeADFHMM8g0KDeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfLi_kYGRiZGBpbG5uaOhMXGqAJp-KLo |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences Physics |
| DocumentTitleAlternate | ANTICORPS VHH À DOMAINE UNIQUE CONTRE HANTAVIRUS |
| ExternalDocumentID | WO2024209377A1 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_WO2024209377A13 |
| IEDL.DBID | EVB |
| IngestDate | Fri Oct 25 05:39:38 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English French |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_WO2024209377A13 |
| Notes | Application Number: WO2024IB53265 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241010&DB=EPODOC&CC=WO&NR=2024209377A1 |
| ParticipantIDs | epo_espacenet_WO2024209377A1 |
| PublicationCentury | 2000 |
| PublicationDate | 20241010 |
| PublicationDateYYYYMMDD | 2024-10-10 |
| PublicationDate_xml | – month: 10 year: 2024 text: 20241010 day: 10 |
| PublicationDecade | 2020 |
| PublicationYear | 2024 |
| RelatedCompanies | UNIVERSIDAD AUSTRAL DE CHILE FUNDACIÓN CIENCIA PARA LA VIDA |
| RelatedCompanies_xml | – name: UNIVERSIDAD AUSTRAL DE CHILE – name: FUNDACIÓN CIENCIA PARA LA VIDA |
| Score | 3.5688276 |
| Snippet | The present invention provides alpaca derived VHHs, therapeutic agents, compositions and methods for the prevention, amelioration and treatment of Hantavirus... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING |
| Title | SINGLE DOMAIN VHH ANTIBODIES AGAINST HANTAVIRUS |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241010&DB=EPODOC&locale=&CC=WO&NR=2024209377A1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La8MwDBale962bmOPbgQ2cgvNs8kOZaR5NBlrUpo0663YaQKDkZY1Y39_skm3nopPlkDIBkn-bEkGeCIUhykXEsHYJOmGgX7QVC3JtHKZmiXVicFqh8dRP5jpr3Nj3oLPbS0M7xP6w5sjokXlaO8199fr_0ssl-dWbnr0A0mrFz8duGKDjjEcIb4Q3eHAm8Ru7IiOg7hNjKacpyJ6N00bsdIBa7zFOu172ZDVpax3g4p_BocTlFfV59Aqqg6cONu_1zpwPG6evDtwxHM08w0SGzvcXEAvCaPRmye48dgOIyELAsGO0nAYs9OdYI-QmKRCgDQ7C6ez5BIefS91Agl1WPwtefEe7yqsXUG7WlXFNQjPKl3SvJ_LRCN6SRSCNmiVCENkqhlLTbmB7j5Jt_vZd3DKpsw3K3IX2vXXd3GPQbemD3yvfgGSdn_Z |
| link.rule.ids | 230,308,780,885,25564,76547 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8JAEJ4QfOBNUeMDtYmmt4aWtiweiOkDaJW2hJbKjeyWkpiYQqTGv-_sBpQT2dtMMpndZB7f7s4MwBNluIiaKxRjk2KYJvpB0uoopJOpjCyYQU1eOxyEbW9ivE7NaQU-t7Uwok_oj2iOiBaVob2Xwl-v_i-xXPG3ct1kH0havvSTritv0DGGI8QXsmt3e6PIjRzZcRC3yeFY8FqI3gmxECsdED5zlydPqc3rUla7QaV_CocjlFeUZ1DJizrUnO3stTocB5sn7zociT-a2RqJGztcn0Mz9sPBsCe5UWD5oZR6nmSFiW9HPLuTrAES40TykGal_ngSX8Bjv5c4noI6zP62PHuPdhXWL6FaLIv8CqTnFpuzrJ2pVKfGgmoUbbCzQBiiMt2c69o1NPZJutnPfoCalwTD2dAP327hhLO4n9bUBlTLr-_8DgNwye7Fuf0CutiCyg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=SINGLE+DOMAIN+VHH+ANTIBODIES+AGAINST+HANTAVIRUS&rft.inventor=TISCHLER%2C+Nicole&rft.inventor=VALENZUELA-NIETO%2C+Guillermo&rft.inventor=JARA%2C+Ronald&rft.inventor=MUENA+CASTILLO%2C+Nicol%C3%A1s+Alvaro&rft.inventor=ROJAS-FERN%C3%81NDEZ%2C+Alejandro&rft.date=2024-10-10&rft.externalDBID=A1&rft.externalDocID=WO2024209377A1 |