6-ALKOXYPYRAZOLOPYRIMIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF

• Main Authors: NISHIMARU, Tatsuya, OHBA, Yusuke, OGOSHI, Yosuke, ADACHI, Kaoru, SAKURAI, Kentaro
• Format: Patent
• Language: English; French; Japanese
• Published: 29.08.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are: a 6-alkoxypyrazolopyrimidine compound and a pharmaceutically acceptable salt thereof that have an inhibitory activity on NLRP3 inflammasomes; a pharmaceutical composition containing the same; and a pharmaceutical use thereof. A compound of formula [I] or a pharmaceutically acceptable salt thereof (in the formula, each symbol is as defined in the description). L'invention concerne : un composé 6-alcoxypyrazolopyrimidine et un sel pharmaceutiquement acceptable de celui-ci qui ont une activité inhibitrice sur les inflammasomes NLRP3 ; une composition pharmaceutique le contenant ; et une utilisation pharmaceutique de celui-ci. L'invention concerne un composé de formule [I] ou un sel pharmaceutiquement acceptable de celui-ci (dans la formule, chaque symbole est tel que défini dans la description). ＮＬＲＰ３インフラマソーム阻害活性を有する６－アルコキシピラゾロピリミジン化合物又はその製薬上許容される塩、それを含む医薬組成物、及びその医薬用途等が提供される。 式［Ｉ］の化合物又はその製薬上許容される塩（式中の各記号は明細書中で定義したとおりである）。