ENGINEERED AAV POLYPEPTIDES

The present disclosure provides engineered AAV capsid polypeptides, engineered MAAP polypeptides, and engineered AAP polypeptides as well as recombinant polynucleotides encoding the engineered AAV polypeptides. The present disclosure further provides use of the engineered AAV polypeptides and recomb...

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Main Authors SEDIGHI, Faezeh, CHNG, Chinping, KUMAR, Ambuj, SERO, Antoinette, ROHOVIE, Marcus, WONG, Victoria, AKEEFE, Hassibullah, GEBRETSADIK, Kahsay, SCHMITT, Christopher, DEL GRECO, Elizabeth, SILVERMAN, Adam, KRUSE, Nikki, DESAUTEL, Sarah, RIVERA-VELAZQUEZ, Mirella
Format Patent
LanguageEnglish
French
Published 08.08.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present disclosure provides engineered AAV capsid polypeptides, engineered MAAP polypeptides, and engineered AAP polypeptides as well as recombinant polynucleotides encoding the engineered AAV polypeptides. The present disclosure further provides use of the engineered AAV polypeptides and recombinant polynucleotides for producing rAAV viruses or rAAV virions. La présente divulgation concerne des polypeptides de capside d'AAV modifiés, des polypeptides MAAP modifiés et des polypeptides AAP modifiés ainsi que des polynucléotides recombinants codant pour les polypeptides AAV modifiés. La présente divulgation concerne en outre l'utilisation des polypeptides AAV modifiés et des polynucléotides recombinants pour produire des virus rAAV ou des virions rAAV.
Bibliography:Application Number: WO2024US14362