ENHANCEMENT OF SYNAPTOGENESIS BY ACTIVATION OF TENEURINS

Methods are provided for enhancing synaptogenesis. It is shown herein that the receptor for the circulating factor SPARCL1 (secreted protein acidic and rich in cysteine-like protein) are teneurin proteins (Tenm1-4). The binding site for SPARCL1 is localized to domain 3, which specifically binds to t...

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Bibliographic Details
Main Authors SUDHOF, Thomas C, ZHANG, Xuchen, GAN, Kathlyn J
Format Patent
LanguageEnglish
French
Published 08.08.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:Methods are provided for enhancing synaptogenesis. It is shown herein that the receptor for the circulating factor SPARCL1 (secreted protein acidic and rich in cysteine-like protein) are teneurin proteins (Tenm1-4). The binding site for SPARCL1 is localized to domain 3, which specifically binds to the C terminal domain of SPARCL1 (SPARCL1-C). Contacting neuronal cells expressing a teneurin protein with SPARC is sufficient to increase synapse formation on the neuronal cells. L'invention concerne des procédés d'amélioration de la synaptogenèse. Il est démontré ici que le récepteur pour le facteur circulant SPARCL1 (protéine sécrétée, acide et riche en protéine de type cystéine) sont des protéines de téneurine (Tenm1-4). Le site de liaison pour SPARCL1 est localisé dans le domaine 3, qui se lie spécifiquement au domaine C-terminal de SPARCL1 (SPARCL1-C). La mise en contact de cellules neuronales exprimant une protéine de téneurine avec SPARC est suffisante pour augmenter la formation de synapses sur les cellules neuronales.
Bibliography:Application Number: WO2024US14098