PYRIDIN-2(1H)-ONES AND PYRIMIDIN-4(3H)-ONES AS NLRP3 INHIBITORS

Provided are compounds for use as inhibitors of the NLRP3 inflammasone pathway, wherein such compounds are as defined by compounds of formula (I) and wherein the radicals R1 to R5 and L are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the...

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Main Authors PRIERI, Marion Laurence Christiane, PEREZ BENITO, Laura, MAMMOLITI, Oscar, MURATORE, Michael Eric, JERHAOUI, Soufyan, OEHLRICH, Daniel, RYABCHUK, Pavel, CAÑELLAS ROMAN, Santiago
Format Patent
LanguageEnglish
French
Published 08.08.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are compounds for use as inhibitors of the NLRP3 inflammasone pathway, wherein such compounds are as defined by compounds of formula (I) and wherein the radicals R1 to R5 and L are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity. L'invention concerne des composés destinés à être utilisés en tant qu'inhibiteurs de la voie de l'inflammasone NLRP3, de tels composés étant tels que définis par les composés de formule (I) et les radicaux R1 à R5 et L étant définis dans la description, et ces composés pouvant être utiles en tant que médicaments, par exemple pour une utilisation dans le traitement d'une maladie ou d'un trouble qui est associé à l'activité de l'inflammasome NLRP3.
Bibliography:Application Number: WO2024EP51982