LIGHT-EXPRESSING IMMUNORESPONSIVE CELLS AND USES THEREOF

• Main Authors: DANIYAN, Antony, CAI, Winson
• Format: Patent
• Language: English; French
• Published: 04.07.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The presently disclosed subject matter provides immunoresponsive cells comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR)), and expressing LIGHT. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and have enhanced immune-activating pr...