LIGHT-EXPRESSING IMMUNORESPONSIVE CELLS AND USES THEREOF
The presently disclosed subject matter provides immunoresponsive cells comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR)), and expressing LIGHT. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and have enhanced immune-activating pr...
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| Main Authors | , |
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| Format | Patent |
| Language | English French |
| Published |
04.07.2024
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The presently disclosed subject matter provides immunoresponsive cells comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR)), and expressing LIGHT. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and have enhanced immune-activating properties.
La présente invention divulgue des cellules immunoréactives comprenant un récepteur de reconnaissance d'antigène (par exemple, un récepteur d'antigène chimérique (CAR)), et exprimant LIGHT. Selon certains modes de réalisation, les cellules immunoréactives modifiées sont dirigées contre l'antigène et ont des propriétés d'activation immunitaire améliorées. |
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| AbstractList | The presently disclosed subject matter provides immunoresponsive cells comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR)), and expressing LIGHT. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and have enhanced immune-activating properties.
La présente invention divulgue des cellules immunoréactives comprenant un récepteur de reconnaissance d'antigène (par exemple, un récepteur d'antigène chimérique (CAR)), et exprimant LIGHT. Selon certains modes de réalisation, les cellules immunoréactives modifiées sont dirigées contre l'antigène et ont des propriétés d'activation immunitaire améliorées. |
| Author | CAI, Winson DANIYAN, Antony |
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| DocumentTitleAlternate | CELLULES IMMUNORÉACTIVES EXPRIMANT LIGHT ET LEURS UTILISATIONS |
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| Snippet | The presently disclosed subject matter provides immunoresponsive cells comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR)),... |
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| Title | LIGHT-EXPRESSING IMMUNORESPONSIVE CELLS AND USES THEREOF |
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