LIGHT-EXPRESSING IMMUNORESPONSIVE CELLS AND USES THEREOF

The presently disclosed subject matter provides immunoresponsive cells comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR)), and expressing LIGHT. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and have enhanced immune-activating pr...

Full description

Saved in:
Bibliographic Details
Main Authors DANIYAN, Antony, CAI, Winson
Format Patent
LanguageEnglish
French
Published 04.07.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The presently disclosed subject matter provides immunoresponsive cells comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR)), and expressing LIGHT. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and have enhanced immune-activating properties. La présente invention divulgue des cellules immunoréactives comprenant un récepteur de reconnaissance d'antigène (par exemple, un récepteur d'antigène chimérique (CAR)), et exprimant LIGHT. Selon certains modes de réalisation, les cellules immunoréactives modifiées sont dirigées contre l'antigène et ont des propriétés d'activation immunitaire améliorées.
Bibliography:Application Number: WO2023US86415