NOR1 LIGANDS AND METHODS OF THEIR USE
Various embodiments relate generally to ligands that bind to the neuron-derived orphan receptor-1 protein-ligand binding domain (Nor1-LBD) and modulate the activity of Nor1, and methods of using Nor1-modulating ligands. In particular, through structural characterisation of the ligand binding domain...
Saved in:
| Main Authors | , |
|---|---|
| Format | Patent |
| Language | English French |
| Published |
23.05.2024
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Various embodiments relate generally to ligands that bind to the neuron-derived orphan receptor-1 protein-ligand binding domain (Nor1-LBD) and modulate the activity of Nor1, and methods of using Nor1-modulating ligands. In particular, through structural characterisation of the ligand binding domain of Nor1, ligands of the Nor1-LBD have been identified along with potential therapeutic uses in treating or preventing associated conditions or diseases thereof.
Divers modes de réalisation concernent de manière générale des ligands qui se lient à la protéine du récepteur orphelin dérivé des neurones-1-domaine de liaison au ligand (Nor1-LBD) et modulent l'activité de Nor1, et des méthodes d'utilisation de ligands modulant Nor1. En particulier, par caractérisation structurale du domaine de liaison au ligand de Nor1, des ligands de Nor1-LBD ont été identifiés, ainsi que des utilisations thérapeutiques potentielles dans le traitement ou la prévention d'états ou de maladies associés. |
|---|---|
| AbstractList | Various embodiments relate generally to ligands that bind to the neuron-derived orphan receptor-1 protein-ligand binding domain (Nor1-LBD) and modulate the activity of Nor1, and methods of using Nor1-modulating ligands. In particular, through structural characterisation of the ligand binding domain of Nor1, ligands of the Nor1-LBD have been identified along with potential therapeutic uses in treating or preventing associated conditions or diseases thereof.
Divers modes de réalisation concernent de manière générale des ligands qui se lient à la protéine du récepteur orphelin dérivé des neurones-1-domaine de liaison au ligand (Nor1-LBD) et modulent l'activité de Nor1, et des méthodes d'utilisation de ligands modulant Nor1. En particulier, par caractérisation structurale du domaine de liaison au ligand de Nor1, des ligands de Nor1-LBD ont été identifiés, ainsi que des utilisations thérapeutiques potentielles dans le traitement ou la prévention d'états ou de maladies associés. |
| Author | YOON, Ho Sup YOO, Jun Yeob |
| Author_xml | – fullname: YOON, Ho Sup – fullname: YOO, Jun Yeob |
| BookMark | eNrjYmDJy89L5WRQ9fMPMlTw8XR39HMJVgASCr6uIR7-QLa_m0KIh6tnkEJosCsPA2taYk5xKi-U5mZQdnMNcfbQTS3Ij08tLkhMTs1LLYkP9zcyMDIxNDA3NLRwNDQmThUA5UYldQ |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | LIGANDS DE NOR1 ET LEURS MÉTHODES D'UTILISATION |
| ExternalDocumentID | WO2024107118A1 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_WO2024107118A13 |
| IEDL.DBID | EVB |
| IngestDate | Fri Sep 20 10:15:38 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English French |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_WO2024107118A13 |
| Notes | Application Number: WO2023SG50766 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240523&DB=EPODOC&CC=WO&NR=2024107118A1 |
| ParticipantIDs | epo_espacenet_WO2024107118A1 |
| PublicationCentury | 2000 |
| PublicationDate | 20240523 |
| PublicationDateYYYYMMDD | 2024-05-23 |
| PublicationDate_xml | – month: 05 year: 2024 text: 20240523 day: 23 |
| PublicationDecade | 2020 |
| PublicationYear | 2024 |
| RelatedCompanies | NANYANG TECHNOLOGICAL UNIVERSITY |
| RelatedCompanies_xml | – name: NANYANG TECHNOLOGICAL UNIVERSITY |
| Score | 3.5414352 |
| Snippet | Various embodiments relate generally to ligands that bind to the neuron-derived orphan receptor-1 protein-ligand binding domain (Nor1-LBD) and modulate the... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | NOR1 LIGANDS AND METHODS OF THEIR USE |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240523&DB=EPODOC&locale=&CC=WO&NR=2024107118A1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_GFPVNp-J0SkDtW9F-pn0YsvXDTmwzuk73Npq0giBzuIr_vtfQ6Z72Ei4JXD7gcvfL5S4AN4VLdZ5ToaJu4KqplbrqClqobsEpLUvT1d7q4OQ4saOp-TSzZi34WMfCyDyhPzI5IkqUQHmv5Hm9_L_E8uXbytUdf8emz4cw6_tKg45RPSGwUvxhPxgzn3mK5yFuU5JU9iHSQXN6gFhpp068VWfaD16GdVzKclOphIewO0Z-i-oIWuWiA_ve-u-1DuzFjcsbyUb6Vsdwm7BUI8-jx0HiTwgWJA6yiCHNQpJFwSgl00lwAtdhkHmRiuPN_5Y3f2WbkzNOoY3AvzwDIhzHproucqEZpmFzx70XljCKwhI5mhFWF3rbOJ1v776Ag7pae8J1owft6uu7vEQFW_EruS-_WeB5lg |
| link.rule.ids | 230,308,780,885,25564,76547 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5KFetNq2K1akDNLWhe3eRQpM3DRPMoaaq9hewmgiC12Ih_39mQak-9LMsOzD5gdubb2ZkBuClMotCcMAl1A5U0uVQkk5FCMgtKSFlqpvzGg5PDaODNtKe5Pm_BxzoWps4T-lMnR0SJYijvVX1fL_8fsez6b-Xqjr7j0OeDmw5tsUHHqJ4QWIn2eOhMYju2RMtC3CZGSU1DpIPm9Aix0g7hNXe58fQy5nEpy02l4h7A7gT5LapDaJWLLnSsde21LuyFjcsbu430rY7gNooTWQj8x1FkTwVshNBJvRj7sSuknuMnwmzqHMO166SWJ-F82d_2std4c3HqCbQR-JenIDDDGBBFYTmTVU0dUMO8ZzpTi0JnOZoReg_62zidbSdfQcdLwyAL_Oj5HPY5iXvFFbUP7erru7xAZVvRy_qMfgE2MnyH |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=NOR1+LIGANDS+AND+METHODS+OF+THEIR+USE&rft.inventor=YOON%2C+Ho+Sup&rft.inventor=YOO%2C+Jun+Yeob&rft.date=2024-05-23&rft.externalDBID=A1&rft.externalDocID=WO2024107118A1 |