SINGLE DOMAIN ANTIBODY - SDAB/VHH AGAINST THE NUCLEOPROTEIN OF SARS-COV-2 VIRUS

• Main Authors: VALENZUELA-NIETO, Guillermo, BERKING, Anne, JARA, Ronald, ROJAS-FERNANDEZ, Alejandro
• Format: Patent
• Language: English; French
• Published: 02.05.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The invention provides a set of new single domain antibodies - sdAb/Vhh against the nucleoprotein (N) of SARS-CoV-2 and their use for diagnostic, therapeutic and prophylactic applications. Wherein the Vhh is selected from Vhh1 and/ or Vhh2 wherein the Vhh1 comprises 3 CDR having at least a 90% identity with aminoacidic sequence according to SEQ ID No 5, 6 and 7, and Vhh2 comprises 3 CDR having at least a 90% identity with aminoacidic sequence according to SEQ ID No 8, 9 and 10. L'invention concerne un ensemble de nouveaux anticorps à domaine unique -sdAb/Vhh dirigé contre la nucléoprotéine (N) du SARS-CoV-2 et leur utilisation pour des applications diagnostiques, thérapeutiques et prophylactiques. Le Vhh étant choisi parmi Vhh1 et/ou Vhh2, le Vhh1 comprenant 3 CDR ayant au moins une identité de 90 % avec une séquence aminoacide selon SEQ ID No 5, 6 et 7, et Vhh2 comprenant 3 CDR ayant au moins une identité de 90 % avec une séquence aminoacide selon SEQ ID No 8, 9 et 10.