COMPOUNDS FOR THE MANAGEMENT OF CELL STEMNESS AND INVASION IN CANCER AND RELATED DISEASES

• Main Authors: MARÍN VIEIRA, María Del Carmen, MARTÍN LÓPEZ, Marta, CAÑEDO HERNÁNDEZ, María Librada, FERNÁNDEZ MEDARDE, Antonio, MARQUÉS MARTÍNEZ, Margarita M, VILLOCH FERNÁNDEZ, Javier, SÁNCHEZ LÓPEZ, José María, VINUESA NAVARRO, María de los Ángeles
• Format: Patent
• Language: English; French
• Published: 11.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to compound of general formula (I): wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in cancer such as Glioblastoma. The compounds have shown to be useful in therapy as modulators of TAP73 and sternness- and invasiveness-related genes. The compounds may be isolated from the fermentation broth of a fungal strain of Chaetomium sp., or are derivatives thereof. The strain of Chaetomium sp. HT-GU-SUES-904 with accession number CECT 20840 is also claimed. La présente invention concerne un composé de formule générale (I) : dans laquelle les variables prennent les diverses significations indiquées, des compositions pharmaceutiques les contenant et leur utilisation en médecine, en particulier contre les cancers tels que le glioblastome. Les composés se sont avérés utiles dans le cadre d'un traitement en tant que modulateurs de TAP73 et de gènes liés au caractère souche et à l'invasivité. Les composés peuvent être isolés du milieu de fermentation d'une souche fongique de Chaetomium sp, ou en dériver. L'invention concerne également la souche de Chaetomium sp. HT-GU-SUES-904 portant le numéro CECT 20840.