SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS

A method of inhibiting propagation of protein misfolding associated with a neurological disease, is carried out by contacting an environment populated with a propagating amyloid conformation of a protein (prion) associated with a neurological disease with molecules which binds multiple adjacent site...

Full description

Saved in:
Bibliographic Details
Main Authors HUTT, Darren, LY, Cuong Quoc, SASAKI, Koji, SIN, Ny, HONZUMI, Masatoshi, MERZ, Gregory E, PARAS, Nick A, IWAMOTO, Osamu, OLSON, Steven H, PRUSINER, Stanley B, RAIKAR, Sandeep, YAMANOI, Shigeo, SOUTHWORTH, Daniel R, VIART, Helene, GRANDJEAN, Jean-Marc M, SUZUKI, Yamato, VANDER WAL, Mark, AYERS, Jacob I, HIRANO, Shimpei, TENGEIJI, Atsushi, WEST, John, CONRAD, Jay, INOUE, Masahiro
Format Patent
LanguageEnglish
French
Published 21.03.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:A method of inhibiting propagation of protein misfolding associated with a neurological disease, is carried out by contacting an environment populated with a propagating amyloid conformation of a protein (prion) associated with a neurological disease with molecules which binds multiple adjacent sites of the protein assemblies and allowing the molecules to bind multiple cites of the protein assemblies; and thereby impeding propagation of the disease-associated conformation of the protein in the environment. Drug/prion complexes are formed and uses of the drugs in detection and treatment of neurodegenerative diseases are disclosed. L'invention concerne un procédé permettant d'inhiber la propagation du mauvais repliement protéique associé à une maladie neurologique qui est réalisé par mise en contact d'un environnement peuplé avec une conformation amyloïde de propagation d'une protéine (prion) associée à une maladie neurologique avec des molécules qui se lient à de multiples sites adjacents des ensembles protéiques et permettant aux molécules de se lier à plusieurs sites des ensembles protéiques ; et empêchant ainsi la propagation de la conformation associée à une maladie de la protéine dans l'environnement. L'invention concerne en outre la formation de complexes médicament/prion et des utilisations des médicaments dans la détection et le traitement de maladies neurodégénératives.
Bibliography:Application Number: WO2023US74382