COMBINATION THERAPIES FOR TREATMENT OF CANCER

• Main Authors: ANDERTON, Judith, KINNEER, Krista, ZERON-MEDINA CUAIRAN, Jorge, LUHESHI, Nadia, PALMER, Doug, ACHOUR, Ikbel, OMAR, Bilal, HAMMOND, Scott A, FREEMAN, Daniel J
• Format: Patent
• Language: English; French
• Published: 01.02.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are methods of treating cancer in a human subject, comprising administering to the subject: i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor. Further provided herein are kits comprising i) an antibody-drug conjugate (ADC) comprising an antibody, a cleavable linker and a cytotoxic agent, and ii) a bispecific checkpoint inhibitor. L'invention concerne des méthodes de traitement du cancer chez un sujet humain, comprenant l'administration au sujet : i) d'un conjugué anticorps-médicament (ADC) comprenant un anticorps, un lieur clivable et un agent cytotoxique, et ii) d'un inhibiteur de point de contrôle bispécifique. L'invention concerne en outre des kits comprenant i) un conjugué anticorps-médicament (ADC) comprenant un anticorps, un lieur clivable et un agent cytotoxique, et ii) un inhibiteur de point de contrôle bispécifique.