NANOCOMPOSITE HYDROGEL

• Main Authors: ABDELMONEIM, Dina, DUNCAN, Warwick John, LIM, Shen Khoon, LI, Kai Chun, COATES, Dawn Elizabeth, COTTON, Gemma Claire, MOLTENO, Nina May
• Format: Patent
• Language: English; French
• Published: 01.02.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS

The invention relates to an anti-microbial gelatin-methacryloyl (GelMA) hydrogel nanocomposite comprising capped silver nanoparticles (AgNP). The nanocomposite hydrogel can be combined with bone graft material to form a bone graft construct. The bone graft construct enhances osteointegration in dentil and surgical bone regeneration applications. L'invention concerne un nanocomposite d'hydrogel de gélatine-méthacryloyle (GelMA) antimicrobien comprenant des nanoparticules d'argent coiffées (AgNP). L'hydrogel nanocomposite peut être combiné avec un matériau de greffe osseuse pour former une construction de greffe osseuse. La construction de greffe osseuse améliore l'ostéointégration dans les applications de régénération osseuse dentaire et chirurgicale.