IMIDAZOTRIAZINE DERIVATIVES AS IL-17 MODULATORS

A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of Formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. L'invent...

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Main Authors STRAKER, Robert, TOWNSEND, Robert James, HASLETT, Gregory William, TAYLOR, Richard David, TRANI, Giancarlo, BRACE, Gareth Neil, NORMAN, Timothy John, GOLDSMITH, Paul
Format Patent
LanguageEnglish
French
Published 25.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of Formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. L'invention concerne série de dérivés d'imidazo[l,2-b] [1,2,4]triazine substitués de formule (I) tels que définis dans la description, qui sont de puissants modulateurs de l'activité de l'IL-17 humaine, lesdits dérivés étant par conséquent utiles dans le traitement et/ou la prévention de diverses affections humaines, y compris des troubles inflammatoires et auto-immuns.
AbstractList A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of Formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. L'invention concerne série de dérivés d'imidazo[l,2-b] [1,2,4]triazine substitués de formule (I) tels que définis dans la description, qui sont de puissants modulateurs de l'activité de l'IL-17 humaine, lesdits dérivés étant par conséquent utiles dans le traitement et/ou la prévention de diverses affections humaines, y compris des troubles inflammatoires et auto-immuns.
Author HASLETT, Gregory William
BRACE, Gareth Neil
NORMAN, Timothy John
STRAKER, Robert
TRANI, Giancarlo
TAYLOR, Richard David
TOWNSEND, Robert James
GOLDSMITH, Paul
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– fullname: TOWNSEND, Robert James
– fullname: HASLETT, Gregory William
– fullname: TAYLOR, Richard David
– fullname: TRANI, Giancarlo
– fullname: BRACE, Gareth Neil
– fullname: NORMAN, Timothy John
– fullname: GOLDSMITH, Paul
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DocumentTitleAlternate DÉRIVÉS D'IMIDAZOTRIAZINE UTILISÉS COMME MODULATEURS DE L'IL-17
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Snippet A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of Formula (I) as defined herein, being potent modulators of human IL-17 activity, are...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title IMIDAZOTRIAZINE DERIVATIVES AS IL-17 MODULATORS
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