METHODS FOR THE ENHANCEMENT OF THERAPEUTIC EFFECT OF CAR-T CELLS

Provided herein is the use of LSD1 inhibitors, in particular bomedemstat, in connection with use and manufacture of immune effector cells such as NK cells and T cells engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, associated with expression of a tumor a...

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Bibliographic Details
Main Author RIENHOFF, Hugh
Format Patent
LanguageEnglish
French
Published 23.11.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein is the use of LSD1 inhibitors, in particular bomedemstat, in connection with use and manufacture of immune effector cells such as NK cells and T cells engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, associated with expression of a tumor antigen. L'invention concerne l'utilisation d'inhibiteurs de LSD1, en particulier de bomédemstat, en liaison avec l'utilisation et la fabrication de cellules effectrices immunitaires telles que des cellules NK et des cellules T modifiées pour exprimer un récepteur antigénique chimérique (CAR), pour traiter un sujet ayant une maladie, associée à l'expression d'un antigène tumoral.
Bibliography:Application Number: WO2023US67222