METHODS AND COMPOSITIONS FOR TREATING VISION LOSS

• Main Authors: REUBINOFF, Benjamin Eithan, KHANER, Hanita, NEEMAN, Dana Hayoun, WISER, Ofer, SKALITER, Rami
• Format: Patent
• Language: English; French
• Published: 02.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

Described herein are methods for differentiating human pluripotent stem cells into populations of retinal cells comprising photoreceptor neural cells (PNCs) in dynamic culture. Also provided are cells and cellular compositions obtained by such methods, and uses of such cells in a suspension or imbedded in a scaffold that can be administered to a subject suffering from a retinal disease or disorder. La présente invention concerne des procédés de différenciation de cellules souches pluripotentes humaines en populations de cellules rétiniennes comprenant des cellules neurales photoréceptrices (PNC) en culture dynamique. L'invention concerne également des cellules et des compositions cellulaires obtenues par de tels procédés, et des utilisations de telles cellules dans une suspension ou incorporées dans un échafaudage qui peut être administré à un sujet souffrant d'une maladie ou d'un trouble rétinien.