COMPOUNDS FOR THE DETECTION AND INHIBITION OF COAGULATION PROTEASES
The present invention relates to novel compounds suitable for the detection and/or inhibition of coagulation proteases, specifically APC, flla, fXa, and fXla. The compounds have the structural formala (1) or (X) shown below in which R1, P1, P2, P3, P4, Z, R1x, A1, A2, A3, A4 and Zx are defined herei...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French |
| Published |
21.09.2023
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| Abstract | The present invention relates to novel compounds suitable for the detection and/or inhibition of coagulation proteases, specifically APC, flla, fXa, and fXla. The compounds have the structural formala (1) or (X) shown below in which R1, P1, P2, P3, P4, Z, R1x, A1, A2, A3, A4 and Zx are defined herein. The present invention also relates to compositions comprising the compounds of formula (I) or formula (X) defined herein, to processes for synthesising these compounds and to their use for the treatment and/or detection of diseases and conditions in which coagulation proteases, in particular APC, flla, fXa, and fXla, are implicated.
La présente invention concerne de nouveaux composés appropriés pour la détection et/ou l'inhibition de protéases de coagulation, en particulierAPC, flla, fXa et fXla. Les composés présentent la formule structurale (1) ou (X) présentée ci-dessous, dans laquelle R1, P1, P2, P3, P4, Z, R1x, A1, A2, A3, A4 et Zx sont définis. La présente invention concerne également des compositions comprenant les composés de formule (I) ou de formule (X) définis dans la présente invention, des procédés de synthèse de ces composés, et leur utilisation pour le traitement et/ou la détection de maladies et d'affections dans lesquelles des protéases de coagulation, en particulier APC, flla, fXa et fXla, sont impliquées. |
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| AbstractList | The present invention relates to novel compounds suitable for the detection and/or inhibition of coagulation proteases, specifically APC, flla, fXa, and fXla. The compounds have the structural formala (1) or (X) shown below in which R1, P1, P2, P3, P4, Z, R1x, A1, A2, A3, A4 and Zx are defined herein. The present invention also relates to compositions comprising the compounds of formula (I) or formula (X) defined herein, to processes for synthesising these compounds and to their use for the treatment and/or detection of diseases and conditions in which coagulation proteases, in particular APC, flla, fXa, and fXla, are implicated.
La présente invention concerne de nouveaux composés appropriés pour la détection et/ou l'inhibition de protéases de coagulation, en particulierAPC, flla, fXa et fXla. Les composés présentent la formule structurale (1) ou (X) présentée ci-dessous, dans laquelle R1, P1, P2, P3, P4, Z, R1x, A1, A2, A3, A4 et Zx sont définis. La présente invention concerne également des compositions comprenant les composés de formule (I) ou de formule (X) définis dans la présente invention, des procédés de synthèse de ces composés, et leur utilisation pour le traitement et/ou la détection de maladies et d'affections dans lesquelles des protéases de coagulation, en particulier APC, flla, fXa et fXla, sont impliquées. |
| Author | HUNTINGTON, James Andrew DRAG, Marcin KASPERKIEWICZ-WASILEWSKA, Paulina MODRZYCKA, Sylwia |
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| Snippet | The present invention relates to novel compounds suitable for the detection and/or inhibition of coagulation proteases, specifically APC, flla, fXa, and fXla.... |
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| Title | COMPOUNDS FOR THE DETECTION AND INHIBITION OF COAGULATION PROTEASES |
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