MULTIMERIC T-CELL MODULATORY POLYPEPTIDES AND METHODS OF USE THEREOF

The present disclosure provides T-cell modulatory multimeric polypeptides (TMMPs) that comprise an immunomodulatory polypeptide and that comprise an epitope-presenting Wilms tumor-1 (WT-1) peptide. A TMMP is useful for modulating the activity of a T cell, and for modulating an immune response in an...

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Bibliographic Details
Main Authors LEVISETTI, Matteo G, MARGOSSIAN, Steven Paul, PIENTA, Kenneth James
Format Patent
LanguageEnglish
French
Published 11.05.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present disclosure provides T-cell modulatory multimeric polypeptides (TMMPs) that comprise an immunomodulatory polypeptide and that comprise an epitope-presenting Wilms tumor-1 (WT-1) peptide. A TMMP is useful for modulating the activity of a T cell, and for modulating an immune response in an individual, e.g., for the treatment of a cancer associated with WT-1. La présente divulgation concerne des polypeptides multimères modulateurs de lymphocytes T (TMMP) qui comprennent un polypeptide immunomodulateur et qui comprennent un peptide de la tumeur de Wilms-1 (WT-1) de présentation d'épitope. Un TMMP est utile pour moduler l'activité d'un lymphocyte T, et pour moduler une réponse immunitaire chez un individu, par exemple pour le traitement d'un cancer associé à WT-1.
Bibliography:Application Number: WO2022US79169