MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE

The present disclosure relates to pharmaceutical compounds of the Formula (I), (Ia), (Ib), or (Ic) or a pharmaceutically acceptable salt or composition thereof. Also provided are methods of use of TRPML modulators for treating disorders, the modulators including compounds of the Formula (I), (Ia), (...

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Bibliographic Details
Main Authors IYENGAR, Rajesh R, GRAZIOTTO, John J, LEE, Thomas Wai-Ho, MCCOMAS, Casey Cameron, SCHMIDT, Darby R
Format Patent
LanguageEnglish
French
Published 06.04.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to pharmaceutical compounds of the Formula (I), (Ia), (Ib), or (Ic) or a pharmaceutically acceptable salt or composition thereof. Also provided are methods of use of TRPML modulators for treating disorders, the modulators including compounds of the Formula (I), (Ia), (Ib), or (Ic). Such methods of use include treatment of ciliopathies. La présente invention concerne des composés pharmaceutiques de formule (I), (Ia), (Ib), ou (Ic) ou un sel ou une composition pharmaceutiquement acceptable de ceux-ci. L'invention concerne également des procédés d'utilisation de modulateurs de TRPML pour traiter des troubles, les modulateurs comprenant des composés de Formule (I), (Ia), (Ib), ou (Ic). De tels procédés d'utilisation comprennent le traitement de ciliopathies.
Bibliography:Application Number: WO2022US45210