METHOD OF TREATING MULTIPLE MYELOMA

• Main Authors: SPECTOR, Michael, SOBOLOV-JAYNES, Susan
• Format: Patent
• Language: English; French
• Published: 23.03.2023
• Subjects: BABY COMFORTERS; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE

Provided herein are methods of treating multiple myeloma and methods of inhibiting amyloid formation in a subject. The methods provided herein include the administration of an antibody that binds to misfolded light chains in combination with an anti-CD38 antibody. The anti-CD38 is for example Daratumumab, Isatuximab, CID- 103 (CASI Pharma), or Moro3087 (Morphosys) or a combination thereof. L'invention concerne des méthodes de traitement du myélome multiple et des méthodes d'inhibition de la formation d'amyloïdes chez un sujet. Les méthodes de l'invention comprennent l'administration d'un anticorps qui se lie à des chaînes légères à repliement incorrect en combinaison avec un anticorps anti-CD38. L'anti-CD38 est par exemple le Daratumumab, l'Isatuximab, le CID-103 (CASI Pharma), ou le Moro3087 (Morphosys) ou une combinaison de ceux-ci.