METHODS AND AGENTS FOR MODULATING THE IMMUNE RESPONSE

• Main Authors: SMALE, Stephen T, DOTY, Kevin, SCUMPIA, Philip O, DAMOISEAUX, Robert D
• Format: Patent
• Language: English; French
• Published: 13.04.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Described are agents and methods for modulating an immune response. More particularly, described are various agents and methods for selectively regulating expression of the gene Il12b in live animals, including human patients. Aberrant expression of Il12b is associated with autoinflammatory diseases...