ANTIBODIES AGAINST ROR1 AND USES THEREOF

• Main Authors: WANG, Guannv, XIAO, Zuoxiang, PENG, Jiaping, ZHOU, Dongwen, ZHOU, Wei, MIAO, Hangbin
• Format: Patent
• Language: English; French
• Published: 26.01.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed herein are monoclonal antibodies against ROR1, bispecific antibodies against ROR1 and CD3, nucleic acids comprising the antibodies, vectors comprising the nucleic acids, and host cell comprising the nucleic acids or the vectors. Also disclosed are pharmaceutical compositions and antibody-drug conjugates comprising the antibodies, and therapeutic methods for using the antibodies. L'invention concerne des anticorps monoclonaux contre ROR1, des anticorps bispécifiques contre ROR1 et CD3, des acides nucléiques comprenant les anticorps, des vecteurs comprenant les acides nucléiques, et une cellule hôte comprenant les acides nucléiques ou les vecteurs. L'invention concerne également des compositions pharmaceutiques et des conjugués anticorps-médicament comprenant les anticorps, et des procédés thérapeutiques pour utiliser les anticorps.