MULTISPECIFIC BINDING MOIETIES COMPRISING NOVEL PD-1 BINDING DOMAINS
The present disclosure relates to multispecific binding moieties comprising novel PD- 1 binding domains that have a higher binding affinity for human PD-1 than a reference PD-1 binding domain. Such multispecific binding moieties further provide a comparable, or equal or higher, potency in blocking l...
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Main Authors | , , , |
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Format | Patent |
Language | English French |
Published |
06.10.2022
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Abstract | The present disclosure relates to multispecific binding moieties comprising novel PD- 1 binding domains that have a higher binding affinity for human PD-1 than a reference PD-1 binding domain. Such multispecific binding moieties further provide a comparable, or equal or higher, potency in blocking ligand binding to human PD-1 than a reference PD-1 antibody. The present disclosure in particular relates to multispecific binding moieties comprising a novel PD-1 binding domain and a LAG-3 binding domain. Also provided is a method for treating a disease, in particular a disease associated with a suppressed immune system, such as cancer, with a multispecific binding moiety of the present disclosure. The present disclosure further relates to a vector and cell comprising nucleic acids encoding a novel PD-1 binding domain and a LAG-3 binding domain.
La présente invention concerne des fractions de liaison multispécifiques comprenant de nouveaux domaines de liaison PD-1 qui présentent une affinité de liaison plus élevée pour PD-1 humain qu'un domaine de liaison PD-1 de référence. De telles fractions de liaison multispécifiques offrent en outre une puissance comparable ou égale ou supérieure, dans le blocage du ligand se liant au PD-1 humain par rapport à un anticorps PD-1 de référence. La présente invention concerne en particulier des fractions de liaison multispécifiques comprenant un nouveau domaine de liaison de PD-1 et un domaine de liaison de LAG-3. L'invention concerne également une méthode destinée au traitement d'une maladie, en particulier d'une maladie associée à un système immunitaire supprimé, tel que le cancer, comportant une fraction de liaison multispécifique selon la présente invention. La présente invention concerne en outre un vecteur et une cellule comprenant des acides nucléiques codants pour un nouveau domaine de liaison de PD-1 et un domaine de liaison de LAG-3. |
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AbstractList | The present disclosure relates to multispecific binding moieties comprising novel PD- 1 binding domains that have a higher binding affinity for human PD-1 than a reference PD-1 binding domain. Such multispecific binding moieties further provide a comparable, or equal or higher, potency in blocking ligand binding to human PD-1 than a reference PD-1 antibody. The present disclosure in particular relates to multispecific binding moieties comprising a novel PD-1 binding domain and a LAG-3 binding domain. Also provided is a method for treating a disease, in particular a disease associated with a suppressed immune system, such as cancer, with a multispecific binding moiety of the present disclosure. The present disclosure further relates to a vector and cell comprising nucleic acids encoding a novel PD-1 binding domain and a LAG-3 binding domain.
La présente invention concerne des fractions de liaison multispécifiques comprenant de nouveaux domaines de liaison PD-1 qui présentent une affinité de liaison plus élevée pour PD-1 humain qu'un domaine de liaison PD-1 de référence. De telles fractions de liaison multispécifiques offrent en outre une puissance comparable ou égale ou supérieure, dans le blocage du ligand se liant au PD-1 humain par rapport à un anticorps PD-1 de référence. La présente invention concerne en particulier des fractions de liaison multispécifiques comprenant un nouveau domaine de liaison de PD-1 et un domaine de liaison de LAG-3. L'invention concerne également une méthode destinée au traitement d'une maladie, en particulier d'une maladie associée à un système immunitaire supprimé, tel que le cancer, comportant une fraction de liaison multispécifique selon la présente invention. La présente invention concerne en outre un vecteur et une cellule comprenant des acides nucléiques codants pour un nouveau domaine de liaison de PD-1 et un domaine de liaison de LAG-3. |
Author | MAYES, Patrick PLYTE, Simon Edward NASTRI, Horacio G STEWART, Shaun M |
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DocumentTitleAlternate | FRACTIONS DE LIAISON MULTISPÉCIFIQUES COMPRENANT DE NOUVEAUX DOMAINES DE LIAISON AU PD-1 |
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Snippet | The present disclosure relates to multispecific binding moieties comprising novel PD- 1 binding domains that have a higher binding affinity for human PD-1 than... |
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Title | MULTISPECIFIC BINDING MOIETIES COMPRISING NOVEL PD-1 BINDING DOMAINS |
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