METHODS OF PREDICTING PROGRESSION OF NEUROLOGICAL DISEASE

The disclosure provides for methods of predicting disease progression comprising detecting a modification of one or more disease markers in a glial cell or neuronal cell generated from a skin cell of the subject. The disclosed methods include methods of identifying subjects that are responsive to a...

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Bibliographic Details
Main Authors MEYER, Kathrin, DENNYS-RIVERS, Cassandra, FERRAIUOLO, Laura
Format Patent
LanguageEnglish
French
Published 21.07.2022
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The disclosure provides for methods of predicting disease progression comprising detecting a modification of one or more disease markers in a glial cell or neuronal cell generated from a skin cell of the subject. The disclosed methods include methods of identifying subjects that are responsive to a therapeutic agent and methods of determining effectiveness of a therapeutic agent. La divulgation concerne des procédés de prédiction de la progression d'une maladie comprenant la détection d'une modification d'un ou de plusieurs marqueurs de maladie dans une cellule gliale ou une cellule neuronale générée à partir d'une cellule cutanée du sujet. Les procédés de l'invention comprennent des procédés d'identification de sujets qui sont sensibles à un agent thérapeutique et des procédés de détermination de l'efficacité d'un agent thérapeutique.
Bibliography:Application Number: WO2022US12221