ANTIBODIES AND ANTIGEN BINDING PEPTIDES FOR FACTOR XIA INHIBITORS AND USES THEREOF

• Main Authors: KRYSTEK, JR, AN, Yongmi, RAKESTRAW, Ginger Chao, PINCKNEY, Jason Robert, DILGER, Andrew Karl, YAMNIUK, Aaron Paul, TERRAGNI, Christina, LUETTGEN, Joseph M, SCHNEEWEIS, Lumelle, SHERIFF, Steven, KISH, Kevin, EWING, William R
• Format: Patent
• Language: English; French
• Published: 14.07.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect o...