DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
A drug conjugate or a pharmaceutically acceptable salt thereof. Gabapentin or a derivative thereof is coupled with propofol or a derivative thereof. Compared with a parent drug, the water solubility and bioavailability of the drug conjugate are effectively improved, and the toxic and side effects of...
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Format | Patent |
Language | Chinese English French |
Published |
30.06.2022
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Abstract | A drug conjugate or a pharmaceutically acceptable salt thereof. Gabapentin or a derivative thereof is coupled with propofol or a derivative thereof. Compared with a parent drug, the water solubility and bioavailability of the drug conjugate are effectively improved, and the toxic and side effects of the drug are reduced. Such a drug conjugate has a pharmaceutical effect and can be used for treating and/or preventing central nervous diseases, such as convulsion/epilepsy, migraine, pain and depression.
L'invention concerne un conjugué de médicament ou un sel pharmaceutiquement acceptable de celui-ci. La gabapentine ou un dérivé de celle-ci est couplée au propofol ou à un dérivé de celui-ci. Par comparaison avec un médicament parent, la solubilité dans l'eau et la biodisponibilité du conjugué de médicament sont améliorées de manière efficace, et les effets toxiques et secondaires du médicament sont réduits. Un tel conjugué de médicament a un effet pharmaceutique et peut être utilisé pour traiter et/ou prévenir d |
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AbstractList | A drug conjugate or a pharmaceutically acceptable salt thereof. Gabapentin or a derivative thereof is coupled with propofol or a derivative thereof. Compared with a parent drug, the water solubility and bioavailability of the drug conjugate are effectively improved, and the toxic and side effects of the drug are reduced. Such a drug conjugate has a pharmaceutical effect and can be used for treating and/or preventing central nervous diseases, such as convulsion/epilepsy, migraine, pain and depression.
L'invention concerne un conjugué de médicament ou un sel pharmaceutiquement acceptable de celui-ci. La gabapentine ou un dérivé de celle-ci est couplée au propofol ou à un dérivé de celui-ci. Par comparaison avec un médicament parent, la solubilité dans l'eau et la biodisponibilité du conjugué de médicament sont améliorées de manière efficace, et les effets toxiques et secondaires du médicament sont réduits. Un tel conjugué de médicament a un effet pharmaceutique et peut être utilisé pour traiter et/ou prévenir d |
Author | YANG, Fengshou CHO, Tara WANG, Jiucheng LU, Wudang JIAO, Yaqi LIU, Cecily CAO, Suoding YANG, Ross |
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DocumentTitleAlternate | 一种药物偶联物、及其制备方法和用途 CONJUGUÉ DE MÉDICAMENT, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION |
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RelatedCompanies | WANG, Jiucheng LIPONT PHARMACEUTICAL INC |
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Snippet | A drug conjugate or a pharmaceutically acceptable salt thereof. Gabapentin or a derivative thereof is coupled with propofol or a derivative thereof. Compared... |
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Title | DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF |
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