DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF

A drug conjugate or a pharmaceutically acceptable salt thereof. Gabapentin or a derivative thereof is coupled with propofol or a derivative thereof. Compared with a parent drug, the water solubility and bioavailability of the drug conjugate are effectively improved, and the toxic and side effects of...

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Main Authors CAO, Suoding, LU, Wudang, LIU, Cecily, YANG, Ross, WANG, Jiucheng, JIAO, Yaqi, CHO, Tara, YANG, Fengshou
Format Patent
LanguageChinese
English
French
Published 30.06.2022
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A drug conjugate or a pharmaceutically acceptable salt thereof. Gabapentin or a derivative thereof is coupled with propofol or a derivative thereof. Compared with a parent drug, the water solubility and bioavailability of the drug conjugate are effectively improved, and the toxic and side effects of the drug are reduced. Such a drug conjugate has a pharmaceutical effect and can be used for treating and/or preventing central nervous diseases, such as convulsion/epilepsy, migraine, pain and depression. L'invention concerne un conjugué de médicament ou un sel pharmaceutiquement acceptable de celui-ci. La gabapentine ou un dérivé de celle-ci est couplée au propofol ou à un dérivé de celui-ci. Par comparaison avec un médicament parent, la solubilité dans l'eau et la biodisponibilité du conjugué de médicament sont améliorées de manière efficace, et les effets toxiques et secondaires du médicament sont réduits. Un tel conjugué de médicament a un effet pharmaceutique et peut être utilisé pour traiter et/ou prévenir d
Bibliography:Application Number: WO2020CN138133