INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE
Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2Rα (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response, e.g. in the prevention and treatment of viral infecti...
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| Main Authors | , , , , , , , , , , |
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| Format | Patent |
| Language | English French |
| Published |
28.04.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2Rα (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response, e.g. in the prevention and treatment of viral infections and cancer.
L'invention concerne des hétérodimères de variant d'IL-2 (IL-2v) à demi-vie sérique prolongée ayant une liaison réduite à la sous-unité IL2Rα (CD25). En particulier, l'invention concerne des hétérodimères de Fc-IL -2v et des méthodes de fabrication et d'utilisation, par exemple d'amélioration d'une réponse immunitaire, par exemple dans la prévention et le traitement d'infections virales et du cancer. |
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| AbstractList | Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2Rα (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response, e.g. in the prevention and treatment of viral infections and cancer.
L'invention concerne des hétérodimères de variant d'IL-2 (IL-2v) à demi-vie sérique prolongée ayant une liaison réduite à la sous-unité IL2Rα (CD25). En particulier, l'invention concerne des hétérodimères de Fc-IL -2v et des méthodes de fabrication et d'utilisation, par exemple d'amélioration d'une réponse immunitaire, par exemple dans la prévention et le traitement d'infections virales et du cancer. |
| Author | BACA, Manuel KHAN, Shahzada MUKHERJEE, Prasenjit K NAGEL, Mark R GILMORE, Sarah A HUNG, Magdeleine S TAM, Danny W THOMAS, Majlinda K KANWAR, Manu JAVANBAKHT, Hassan PAPALIA, Giuseppe |
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| DocumentTitleAlternate | PROTÉINES DE FUSION D'INTERLEUKINE-2-FC ET MÉTHODES D'UTILISATION |
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| Title | INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE |
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