SIRNA COMPOSITIONS AND METHODS FOR SILENCING GPAM (GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL) EXPRESSION

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the GPAM gene, as well as methods of inhibiting expression of GPAM, and methods of treating subjects that would benefit from reduction in expression of GPAM, such as subjects having a GPAM-associated disease, di...

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Bibliographic Details
Main Authors MCININCH, James D, BONDURANT, Lucas, DEATON, Aimee
Format Patent
LanguageEnglish
French
Published 16.12.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the GPAM gene, as well as methods of inhibiting expression of GPAM, and methods of treating subjects that would benefit from reduction in expression of GPAM, such as subjects having a GPAM-associated disease, disorder, or condition, using such dsRNA compositions. L'invention porte sur des compositions d'acide ribonucléique double brin (ARNdb) ciblant le gène GPAM, ainsi que des procédés d'inhibition de l'expression de la GPAM, et des méthodes de traitement de patients qui pourraient bénéficier d'une réduction de l'expression de la GPAM, tels que des patients atteints d'une maladie, d'un trouble ou d'un état associé à la GPAM, faisant intervenir de telles compositions d'ARNdb.
Bibliography:Application Number: WO2021US36643