PROCESS OF PREPARING BUTYL-(5S)-5-({2-[4-(BUTOXYCARBONYL)PHENYL]ETHYL}[2-(2-{[3-CHLORO-4'-(TRIFLUOROMETHYL)[BIPHENYL]-4-YL]METHOXY}PHENYL)ETHYL]AMINO)-5,6,7,8-TETRAHYDROQUINOLINE-2-CARBOXYLATE
Die vorliegende Erfindung betrifft ein neues und verbessertes Verfahren zur Herstellung von Butyl-(5S)-5-({2-[4-(butoxycarbonyl)phenyl]ethyl}[2-(2-{[3-chlor-4'-(trifluormethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino)-5,6,7,8-tetrahydrochinolin-2-carboxylat der Formel (XII) neue Vorstufen zu...
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Language | English French German |
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25.11.2021
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Abstract | Die vorliegende Erfindung betrifft ein neues und verbessertes Verfahren zur Herstellung von Butyl-(5S)-5-({2-[4-(butoxycarbonyl)phenyl]ethyl}[2-(2-{[3-chlor-4'-(trifluormethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino)-5,6,7,8-tetrahydrochinolin-2-carboxylat der Formel (XII) neue Vorstufen zu deren Herstellung, sowie die Verwendung zur Herstellung von (5S)-5-{[2-(4-Carboxyphenyl)ethyl][2-(2-{[3-chlor-4'-(trifluormethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydrochinolin-2-carbonsäure.
The invention relates to a new and improved process of preparing butyl-(5S)-5-({2-[4-(butoxycarbonyl)phenyl]ethyl}[2-(2-{[3-chloro-4'-(trifluoromethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino)-5,6,7,8-tetrahydroquinoline-2-carboxylate of formula (XII), new precursors for its preparation, and to its use for preparing (5S)-5-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4'-(trifluoromethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid.
L'invention concerne un procédé nouveau et amélioré de préparation de butyl-(5S)-5-({2-[4-(butoxycarbonyl)phényl]éthyl}[2-(2-{[3-chloro-4'-(trifluorométhyl)[biphényle]-4-yl]méthoxy}phényl)éthyl]amino)-5,6,7,8-tétrahydroquinoléine-2-carboxylate de formule (XII), de nouveaux précurseurs pour sa préparation, et son utilisation pour préparer l'acide (5S)-5-{[2-(4-carboxyphényl)éthyl][2-(2-{[3-chloro-4'-(trifluorométhyl)[biphényle]-4-yl]méthoxy}phényl)éthyl]amino}-5,6,7,8-tétrahydroquinoléine-2-carboxylique. |
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AbstractList | Die vorliegende Erfindung betrifft ein neues und verbessertes Verfahren zur Herstellung von Butyl-(5S)-5-({2-[4-(butoxycarbonyl)phenyl]ethyl}[2-(2-{[3-chlor-4'-(trifluormethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino)-5,6,7,8-tetrahydrochinolin-2-carboxylat der Formel (XII) neue Vorstufen zu deren Herstellung, sowie die Verwendung zur Herstellung von (5S)-5-{[2-(4-Carboxyphenyl)ethyl][2-(2-{[3-chlor-4'-(trifluormethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydrochinolin-2-carbonsäure.
The invention relates to a new and improved process of preparing butyl-(5S)-5-({2-[4-(butoxycarbonyl)phenyl]ethyl}[2-(2-{[3-chloro-4'-(trifluoromethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino)-5,6,7,8-tetrahydroquinoline-2-carboxylate of formula (XII), new precursors for its preparation, and to its use for preparing (5S)-5-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4'-(trifluoromethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid.
L'invention concerne un procédé nouveau et amélioré de préparation de butyl-(5S)-5-({2-[4-(butoxycarbonyl)phényl]éthyl}[2-(2-{[3-chloro-4'-(trifluorométhyl)[biphényle]-4-yl]méthoxy}phényl)éthyl]amino)-5,6,7,8-tétrahydroquinoléine-2-carboxylate de formule (XII), de nouveaux précurseurs pour sa préparation, et son utilisation pour préparer l'acide (5S)-5-{[2-(4-carboxyphényl)éthyl][2-(2-{[3-chloro-4'-(trifluorométhyl)[biphényle]-4-yl]méthoxy}phényl)éthyl]amino}-5,6,7,8-tétrahydroquinoléine-2-carboxylique. |
Author | EGGER, Julian BREMEYER, Nadine NOWAKOWSKI, Marc FEY, Peter |
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DocumentTitleAlternate | VERFAHREN ZUR HERSTELLUNG VON BUTYL-(5S)-5-({2-[4-(BUTOXYCARBONYL)PHENYL]ETHYL}[2-(2-{[3-CHLOR-4'-(TRIFLUORMETHYL)[BIPHENYL]-4-YL]METHOXY}PHENYL)ETHYL]AMINO)-5,6,7,8-TETRAHYDROCHINOLIN-2-CARBOXYLAT PROCÉDÉ DE PRÉPARATION DE BUTYL-(5S)-5-({2-[4-(BUTOXYCARBONYL)PHÉNYL]ÉTHYL}[2-(2-{[3-CHLORO-4'-(TRIFLUOROMÉTHYL)[BIPHÉNYLE]-4-YL]MÉTHOXY}PHÉNYL)ÉTHYL]AMINO)-5,6,7,8-TÉTRAHYDROQUINOLÉINE-2-CARBOXYLATE |
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Title | PROCESS OF PREPARING BUTYL-(5S)-5-({2-[4-(BUTOXYCARBONYL)PHENYL]ETHYL}[2-(2-{[3-CHLORO-4'-(TRIFLUOROMETHYL)[BIPHENYL]-4-YL]METHOXY}PHENYL)ETHYL]AMINO)-5,6,7,8-TETRAHYDROQUINOLINE-2-CARBOXYLATE |
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