ANTIBODY-DRUG CONJUGATES SPECIFIC FOR CD276 AND USES THEREOF

An improved antibody-drug conjugate (ADC) targeting CD276-positive tumors is described. The ADC includes a CD276-specific IgG1 antibody having a heavy chain modified to prevent interaction of its Fc domain with endogenous Fc receptors and to introduce a cysteine for site-specific conjugation of the...

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Bibliographic Details
Main Authors FENG, Yang, SEAMAN, Steven, ST. CROIX, Brad
Format Patent
LanguageEnglish
French
Published 17.06.2021
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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