COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS TYPE 2 COMPETENT FOR ANTIGEN PRESENTATION, METHODS AND USES THEREOF
The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter referred to as "cDC2" or "CD11b-positive dendritic cells"), methods and uses thereof. The present disclosure relates to the de...
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Format | Patent |
Language | English French |
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03.06.2021
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Abstract | The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter referred to as "cDC2" or "CD11b-positive dendritic cells"), methods and uses thereof. The present disclosure relates to the development of methods for making conventional dendritic cells with antigen presenting capacity from differentiated, multipotent or pluripotent stem cells by introducing and expressing isolated/synthetic transcription factors. More particularly, the disclosure provides methods for obtaining conventional dendritic cells (cDC), particularly cDC type 2 or CD11b-positive dendritic cells, by direct cell reprogramming with the surprisingly use of combinations of specific transcription factors.
La présente invention concerne des compositions pour la reprogrammation de cellules en cellules dendritiques classiques (cDC), en particulier dans des cDC de type 2 (ci-après désignées par « cDC2 » ou « cellules dendritiques positives à CD11b »), des procédés et des utilisations associés. La présente invention concerne le développement de procédés de fabrication de cellules dendritiques classiques avec des capacités de présentation d'antigène à partir de cellules souches différenciées, multipotentes ou pluripotentes par introduction et expression de facteurs de transcription isolés/synthétiques. Plus particulièrement, l'invention concerne des procédés pour obtenir des cellules dendritiques classiques (cDC), particulièrement des cDC de type 2 ou des cellules dendritiques positives à CD11b par reprogrammation cellulaire directe avec l'utilisation contre tout attente de combinaisons de facteurs de transcription spécifiques. |
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AbstractList | The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter referred to as "cDC2" or "CD11b-positive dendritic cells"), methods and uses thereof. The present disclosure relates to the development of methods for making conventional dendritic cells with antigen presenting capacity from differentiated, multipotent or pluripotent stem cells by introducing and expressing isolated/synthetic transcription factors. More particularly, the disclosure provides methods for obtaining conventional dendritic cells (cDC), particularly cDC type 2 or CD11b-positive dendritic cells, by direct cell reprogramming with the surprisingly use of combinations of specific transcription factors.
La présente invention concerne des compositions pour la reprogrammation de cellules en cellules dendritiques classiques (cDC), en particulier dans des cDC de type 2 (ci-après désignées par « cDC2 » ou « cellules dendritiques positives à CD11b »), des procédés et des utilisations associés. La présente invention concerne le développement de procédés de fabrication de cellules dendritiques classiques avec des capacités de présentation d'antigène à partir de cellules souches différenciées, multipotentes ou pluripotentes par introduction et expression de facteurs de transcription isolés/synthétiques. Plus particulièrement, l'invention concerne des procédés pour obtenir des cellules dendritiques classiques (cDC), particulièrement des cDC de type 2 ou des cellules dendritiques positives à CD11b par reprogrammation cellulaire directe avec l'utilisation contre tout attente de combinaisons de facteurs de transcription spécifiques. |
Author | FIÚZA, ROSA OLIVEIRA, Luís FERREIRA, PIRES RIBEIRO LEMOS PEREIRA, Carlos |
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DocumentTitleAlternate | COMPOSITIONS DESTINÉES À LA REPROGRAMMATION DE CELLULES EN CELLULES DENDRITIQUES DE TYPE 2 APPROPRIÉES POUR LA PRÉSENTATION D'ANTIGÈNE, PROCÉDÉS ET UTILISATIONS ASSOCIÉS |
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Snippet | The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter... |
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Title | COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS TYPE 2 COMPETENT FOR ANTIGEN PRESENTATION, METHODS AND USES THEREOF |
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