COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN B (APOB) GENE EXPRESSION

The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of an apolipoprotein B (APOB) gene by targeting an APOB expression control region and methods of use thereof for treating an APOB associated disorder, e.g., hypercholesterolemia. L...

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Bibliographic Details
Main Authors FARELLI, Jeremiah D, SCHEIDEGGER, Adam Walter, ASHOK, Patil Vishwesh, SARISOZEN, Can, KARNIK, Rahul, SMITH, Jesse Jerome, BENNETT, Barbara
Format Patent
LanguageEnglish
French
Published 01.04.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of an apolipoprotein B (APOB) gene by targeting an APOB expression control region and methods of use thereof for treating an APOB associated disorder, e.g., hypercholesterolemia. La présente invention concerne des agents et des compositions pour moduler l'expression (par exemple, une expression améliorée ou réduite) d'un gène d'apolipoprotéine B (APOB) par ciblage d'une région de régulation d'expression de APOB et des procédés d'utilisation de celle-ci pour traiter un trouble associé à APOB, par exemple, l'hypercholestérolémie.
Bibliography:Application Number: WO2020US52119