C-NUCLEOSIDES, C-NUCLEOTIDES AND THEIR ANALOGS, EQUIVALENTS AND PRODRUGS THEREOF FOR ECTONUCLEOTIDASE INHIBITION

• Main Authors: OH, Su-Sung, KWON, A Ra, BYEON, Seong Rim, CHOI, Young Il
• Format: Patent
• Language: English; French
• Published: 04.03.2021
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The invention provides novel heterocyclic C-nucleosides, C-nucleotides and their analogues, equivalents, and prodrug thereof. The compounds, compositions, and methods provided of the invention, by themselves or in combination with other therapies are useful for the treatment of a disease, disorder or condition related to CD73 (ecto-5'-nucleotidase) enzyme. L'invention concerne de nouveaux C-nucléosides, C-nucléotides hétérocycliques et leurs analogues, équivalents et promédicaments de ceux-ci. Les composés, les compositions et les procédés selon l'invention, seuls ou en combinaison avec d'autres thérapies, sont utiles pour le traitement d'une maladie, d'un trouble ou d'un état pathologique lié à l'enzyme (ecto-5'-nucléotidase) CD73.